If SF offers the #6, #22 and additional picks this year and/or next I'd do it.
At 6, we'll probably have a choice of some of the following D'Brick, Hawk, V. Davis, Vince and Huff. I'd really like Hawk or Huff to help build our defense. However, Vernon Davis is a beast and could certainly create opportunities on offense.
Then at 22, we could target BPA at CB/S, LB, DE or OL.
Imagine walking out of the draft with AJ Hawk and Jimmy Williams (or Cromartie, Hill, Joesph, Whitner, etc.). Adding quality players like that to our defense would help tremendously. In the 2nd we could target BPA at above areas we didn't cover in 1st. Adding some high energy defenders to the vets we signed would give our defense a definite boost going into our tough early schedule.
We would still have a solid/talented offense, that would benefit from Moulds, Flanagan, Putzier, etc. + new coaches.
Bonus: If we add another 2 or 3 in '07, we continue to build through draft.