I've got the top spot in my draft.

[Mr. White]

Does this mean that I've gotta take LT?

 

[Vinny]

depends on your league structure and size (take I'd take Peyton or Brady in a 8 team league)....some leagues are way too QB friendly with the stats. I'd probably take LT in a conventional league.

 

[TexansLucky13]

LT or AD... pick your poison. I would not take a QB with the #1 pick unless your league has a pass-happy point structure (which normally isn't the case). In most cases RB's are far more valuable.