Flowers, after dropping out of college, was a bellhop for a while at the Gold Coast Hotel and Casino in Las Vegas. In 2001, He was abandoned by the first band that he was in, a synth pop band known as Blush Response, after he declined to move with the rest of them to Los Angeles, California. Shortly thereafter, unexpectedly Flowers attended an Oasis concert, and realizing that he wanted to make the transition from a keyboard band to a true rock band, began searching for a guitarist. He responded to an ad that Dave Keuning had placed in the paper that listed, among other bands, The Cure and Oasis as influences. After several short-lived bassists and drummers, Flowers and Keuning were joined by bassist Mark Stoermer and drummer Ronnie Vannucci and they became the Killers
According to the Las Vegas Review-Journal, his parents have always supported his decision to become a rock singer, and were often the only people in the audience at The Killers' first performances in the band's early days.[citation needed]
Although primarily a vocalist and keyboardist, Flowers plays bass guitar live in concerts for the song "For Reasons Unknown".
