I'd sit Braylon Edwards since he's playing the toughest defense (PIT.) I don't think the Browns will move the ball against them.
It'd be a toss-up between Muhsin Muhammad and Isaac Bruce since they're both playing tough D's as well.
I think the Panthers' D is getting old and they should be on the field a lot because they just changed the offense. I guess for that reason, I'd go with Bruce.