Twelfth Man = Colts Fan
I think the key to this game will be Time of Possession. Whoever can keep their Defense on the bench longest will have the best opportunity to win.
That being said, the Colts TOP stinks this year. But they do tend to score rather quickly at times. Three and out sometimes means TD for the Colts. During the Vikings game I recall one drive where they made a first down every other play. No third down conversion needed.
The Colts had an 8 minute TOP advantage with the Vikings. Maybe they learned something.