Chargers' best bet is to try and get out to an early lead. If they get behind and have to pass it will be a long day. They need to have the lead and be able to feed LT all game long.
Both teams are closely matched, but one important factor being overlooked is the Reliant Stadium advantage. Reliant Stadium is LOUD. Now, I've never been to Arrowhead or any other crazy stadium like that, but I could not imagine it being any louder than Reliant gets. That will be another distraction for S.D.