This is a better example:
Keenum took an unranked UH team into stillwater and beat #5 OSU.
It's a better example, because in 2009 the cougar defense was a disaster and the offense had to win every game in a shootout. OSU had better talent across the board (including NFL talent on offense and defense).
By the time the 2011 Penn State game rolled around, the talent level (and defense) had increased at UH to the point where they were a legitimate top 25 team. (finished #14)
In 2007, Keenum lead a comeback (and almost won) in tuscaloosa against Alabama. Houston lost the game when they came up short in the endzone as time expired after rallying from almost 20 points down -- in front of a crowd of 93,000. He did not start, but came in after the other QB proved incapable of moving the ball.
The guy is used to playing well in big games in front of large crowds.
If he can translate that to the NFL we should be in for some fun times in the future.. If not, he at least got his shot with the hometown good-guys..